Computer Designed Regenerative Heart Valves

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Cardiovascular tissue engineering plans to treat heart disease with prostheses that develop and recover. Presently, analysts from the University of Zurich, the have effectively embedded regenerative heart valves, composed with the guide of computer applications recreations, for the first time.

Delivering living tissue or organs based on human cells is one of the principle look into fields in regenerative drug. Tissue engineering, which includes developing new parts in the lab, frames a key piece of this examination. The parts can be utilized to supplant defective cells and tissues in the body and re-establish their normal working. The bioengineered substitutions don’t cause immune responses in the patient’s body, and they can develop and recover themselves.

An international association led by UZH Professor Simon P. Hoerstrup has now achieved a point of reference out and about towards having the capacity to treat heart patients utilizing new heart valves cultured from human cells: This team for the first time, utilizing computer applications, prevailing in exclusively predicting how very much cultured heart valves would develop, recover, and work in huge creature models (sheep).They optimize the plan and piece of the regenerative heart valves and created altered inserts for use in treatment.

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Valvular heart disease is one of the real reasons for morbidity and mortality around the world. At present accessible artificial heart valve prostheses are an unacceptable arrangement, specifically for kids with congenital heart defects.

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There are as yet a couple of obstacles to get over before the innovation can be routinely utilized even though this field of research is promising and the main clinical employments of heart valves and  blood vessels utilizing tissue engineering have just been made. These heart valves when used are that every patient’s potential for recovery is extraordinary. There is subsequently nobody measure fits-all arrangement”, accentuates Hoerstrup, whose exploration group has been among the pioneers of cardiovascular tissue designing for over 20 years.

Nutritional Psychology

Food Chem

Nutritional Psychology is the study of how nutrients control mood and behaviour. This field study the relationship between food and our internal experience, incandescent the bio physiological mechanisms, determined by our nutrient intake that control mood and behaviour .It may be practiced to numerous different fields including psychology, dietetics, nutrition, and marketing. Nutrition psychology is a quite new field with a sharp   history that has already started to supply information and knowledge to psychology. There are two main areas of discussion within nutrition psychology. The first area of discussion is that the topic can be viewed as nutrition affecting psychological functions or can be viewed as psychological choices and   behavior   determines nutrition and health. The second discussion is the definition of what is healthy or normal as similar to nutrition.

According to the Diagnostic and Statistical standard of Mental Disorders, 4 out of the 10 leading causes of defect in the US and other developed countries are mental defect. This observable distribution can be also explained by studies which show that a lack of certain dietary nutrients afford to the development of mental disorders.

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Most and other regulation drugs cause severe side effects, which usually discourage patients from taking their medicament. Such refractory patients who have mental disorders are at a higher hazard for committing suicide or being regulated. Most and other prescript drugs cause severe side effects, which usually demoralize patients from taking their medicament. Such refractory patients who have mental disorders are at a higher hazard for committing suicide or being regulated. One way for psychiatrists to overthrown this disagreement is to educate themselves about substitute or complemental nutritional treatments. Although in the cases of certain nutrients, further research needs to be done to determine the best recommended doses of most nutritional supplements, psychiatrists can recommend doses of dietary supplements based on previous and current efficacious studies and then adjust the doses based on the results obtained.

ACE Inhibitors and Beta Blockers in treating Cardiotoxicity caused by Trastuzumab

Recent advancements in cancer therapies have helped many patients with breast cancer to achieve better outcomes and longer survival. However, this progress causes the Cardiotoxicity, associated with anticancer therapies, which ranges from subclinical abnormalities to irreversible life-threatening complications, such as cardiomyopathy or congestive heart failure.

Pharma Med Chem

Chemotherapeutics drugs or other medications you may be taking to control your disease may cause the cardiotoxicity where heart may not be able to pump blood throughout body by the damaged heart muscles. One such treatment is by using the Trastuzumab which is a monoclonal antibody used in the treatment of HER2-receptor positive metastatic breast cancer. Which can be used alone or in combination with other chemotherapeutic agents. In addition, it has been indicated that Herceptin can impair the regenerative capacities of human resident cardiac stem cells. Statistical study has been proved that One in four women treated with trastuzumab develops potentially dangerous cardiac problems.

It has been recommended that patients receiving adjuvant treatment with trastuzumab should have adequate cardiac monitoring, using transthoracic ECHO or radionuclide ventriculography multiple-gated acquisition (MUGA) scans at baseline, and then at 3, 6, and 9 months after starting this treatment. Dr. Maya Guglin and his colleagues conducted multicenter clinical trial and showed that ACE inhibitor or a beta-blocker would prevent decreased LVEF that is Cardiotoxicity.

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ACE Inhibitors such as Lisinopril helps the blood vessels to enlarge or dilate, and as a result blood pressure is reduced. This lower blood pressure makes it easier for the heart to pump blood and can improve the function of a failing heart by inhibiting the activity of the Angiotensin converting enzyme (ACE) which leads to the production of Angiotensin II which is potent chemical produced by the body that primarily circulates in the blood. It causes the muscles surrounding blood vessels to contract, thereby narrowing the blood vessels which finally leads to the cause of Cardiotoxicity.

Beta blockers such as Carvedilol serves by blocking the effect of hormone adrenaline also known as Epinephrine. Medications that reduces the blood pressure by helping to open the blood vessels. Which helps in reducing the blood pressure.

World’s Strongest Bio-Material Outperforms Steel and Spider Silk

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Utilizing a novel generation strategy, the specialists have effectively exchanged the one of a kind mechanical properties of these nanofibres to a naturally visible, lightweight material that could be utilized as an eco-accommodating option for plastic in planes, autos, furniture and different items. A nanometer (nm) is a millionth of a millimeter. The nanofibres were suspended in water and encouraged into a little channel, only one millimeter wide and processed in steel. Through two sets of opposite inflows extra deionized water and water with a low pH-esteem entered the channel from the sides, crushing the flood of nanofibres together and quickening it.

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 No paste or some other part is required, the nanofibres collect into a tight string held together by supramolecular powers between the nanofibres, for instance electrostatic and Van der Waals powers. “The X-beams enable us to break down the nitty gritty structure of the string as it shapes and in addition the material structure and progressive request in the super solid filaments,” clarifies co-writer Stephan Roth from DESY, leader of the Micro-and Nanofocus X-beam Scattering Beamline P03 where the strings were spun. “We made strings up to 15 micrometers thick and a few meters long.”

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 “The bio-based nanocellulose strands manufactured here are 8 times stiffer and have qualities higher than common dragline arachnid silk filaments,” says Söderberg. “In the event that you are searching for a bio-based material, there is nothing very like it. What’s more, it is likewise more grounded than steel and some other metal or combination and also glass filaments and most other engineered materials.” “The new material can on a basic level be utilized to make bio-degradable parts,” includes Roth.

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 It opens the path for creating nanofibre material that can be utilized for bigger structures while holding the nanofibres’ rigidity and capacity to withstand mechanical load. “This revelation is made conceivable by understanding and controlling the key central parameters basic for idealize nanostructuring, for example, molecule measure, cooperations, arrangement, dispersion, organize development and get together.

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Ways to Track your Food: Tech World

Tracking Food is the way where you can monitor your Food. Hunger is the body’s in built Food Tracker and one should not kill their hunger to build a un healthy relationship with the Food. Technology is at our hands where one can count their calories and maintain a healthy life without being Insane. Carefully planned meals make us know the calculation of “Calories in and Calories out” and makes a perfect point of weight gain, weight loss or weight management. We need to ensure the master equation to reach the goal of the nutrition through the latest personalized Nutrition Trackers.

Food Tracking

Can Food Tracking be named as “Self-Monitoring of Diet”, there are plenty more to back up the ways of Food Tracking. Scientist’s curiosity has laid a foundational key to the ways of weight loss through Food Tracking. A research review has found the way of positive weight loss and the Food Tracking (Food Intake)  where studies showed the dietary reports. Latest Food Technology gadgets have found a way of tracking food more easier and precise.

Diet Sensor: This has become one gadget where the equipment can scan the food by passing a beam of light and tells the nutrient components in the food along with the amount of Protein, Fat and carbohydrates content. The constituents are calculated by the interaction of the food with the ray of light passed by the Diet Sensor. The sensor passes a beam of infra-red light onto the surface of the food that enables the food molecules to vibrate and allows it to produce optical Signature of the food molecules.

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The drawback of this Diet sensor is that, the scanner works only for the homogeneous food or foods with one layer, for example foods like bread, cheese slices or chicken but not chicken sandwich. There is a data base due use the Diet sensor for non-homogenous foods.  Diet sensor app displays the nutritional content for you to know the amount of food intake taken by you and also advices the portion of food to be taken by you based on your goals of nutritional intake based on the data bases you provide and conditions your health with Diabetes, high cholesterol and makes you fitness expert. New products like Hidrate Spark, Smart diet scale are out in this technological world where the sensor in the Hydrate Spark makes you know the amount of water intake  and Smart diet gives the nutritional information by weighing the food with more precise and accurate values of the calories and nutrient calculations.

Get to know more of such more technological gadgets to make a healthy life, Fitness freaks can get more knowledge at our 2nd International Conference on Nutrition, Food Science and Technology @ Abu Dhabi.

CLINICAL PHARMACY

CLINICAL PHARMACY

Clinical Pharmacy is the study and practise of rational use of medicine. It is the health science that provides patient care that monitors the patient medication treatment and improves health that results in disease control and prevention. Clinical Pharmacy also has the responsibility to educate the future with advanced health care and quality of life. Clinical Pharmacy has been considered as Pharmaceutical Care that was reported as the answerable source of pharmaceutical therapy for the purpose of achieving definite outcomes which improve patients’ quality of life. The birth of the pharmaceutical care concept can be described as a practical philosophy for pharmacy. The concept involves responsibilities, medication surveillance at individual and systems level, counselling, and evaluation of care resultants.

Prescription Medicine

 The pharmacists that perform the clinical role alongside physicians are called as Clinical Pharmacists. They will have direct interaction and good coordination with the physicians and other health professionals and to patients as well to ensure the prescribed medication of the respective patient to promote the best health conditions. The role of Clinical Pharmacists lies in different areas including the healthcare centres and its affiliated outpatient clinics, Emergency departments of the hospitals as Hospital Pharmacists, in place of Community Pharmacies as Community Pharmacists, at Physicians’ Offices, Community or group based clinics, all nursing homes as per requirement and certain managed care organizations which may come under Social-Service centres.

Clinical pharmacy is a major area of the Pharmacy field. All the upcoming pharmacists should be engaged in the improvement of the entire profession. Conversion of the vision into practice will take dedication and facilities. Although, if pharmacy practice is going to continue as the model of drug competence, helping to reach the peaks in health care, now everyone should begin to unite the intermediary of pharmacists to locate the unfilled requirements of our patients and society.

Data Science

How do we relate Data Science, Artificial Intelligence, Machine Learning & Deep Learning with each other?

DATA SCIENCE

 

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It is an interdisciplinary field about processes and systems to extract knowledge or insights from data in various forms. This means that data science helps AI to come out of the problems by linking related kind of data for future use. Basically, information pools faster and more efficiently. They play active roles in the design and implementation work of four related areas:

  • Data architecture
  • Data acquisition
  • Data analysis
  • Data archiving

ARTIFICIAL INTELLIGENCE

AI

In the present, AI is complex and effective but is nowhere equal to human intelligence. Humans use the data present around them and the data accumulated in the past to figure out anything and everything. However, AIs don’t have that ability just yet.

Artificial intelligence is turning up to every industry, but we must understand its limits. The principle limitation of AI is that it learns from the data. There is no other way in which knowledge can be integrated. That means any deception in the data will be reflected in the results. And any additional layers of prediction or analysis must be added separately.

MACHINE LEARNING

Machine Learning

Machine learning is an application of artificial intelligence (AI) that provides systems ability to automatically learn and improve from experience without being exclusively programmed. It focuses on the development of computer programs that can access data and use it to learn for themselves.

The process of learning begins with observations or data, such as examples, direct experience, or instruction, to look for patterns in data and make better decisions in the future based on the examples that we provide. Machine learning methods

  • Supervised machine learning algorithms
  • unsupervised machine learning algorithms
  • Semi-supervised machine learning algorithms
  • Reinforcement machine learning algorithms

DEEP LEARNING

Deep Learning

It is a latest technology behind driverless cars, which enables them to recognize a stop sign, or to make difference between a pedestrian from a lamppost. Models are trained by using a large set of collected data and neural network architectures

HOW AL ML & DL ARE INTERCONNECTED?

Artificial intelligence is a huge term with applications ranging from robotics to text analysis. It is still a technology under evolution and there are dispute of whether we should be aiming for high-level AI or not. Machine learning is a subset of AI that focuses on a definite range of activities.

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Eye Cancer: Things to Know

Cancer of the eye is rare. It damages eyelid by binding of muscles, skin and nerves. When the tumor starts inside the eyeball it is known intraocular cancer. The common intraocular cancers are melanoma and lymphoma. In children, the common eye cancer is retinoblastoma, which is the cancer of the cells of the retina. Cancer cells can spread from eye to other parts of the body when cancer antigen cells begin to grow out of control. Treatment for eye cancer varies- they can be treated surgically, through radiation therapy, freezing/ heat therapy, or laser therapy.

 The eye has 3 major parts: the eyeball, the orbit, and the adnexal structures. Parts of the eye including the conjunctiva, anterior chamber, cornea, lens, iris, ciliary body, orbit, optic nerve, retina and sclera.

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Eyeball

The main part of the eye is the eyeball which is mostly filled with a jelly-like material called vitreous humor. The eyeball has 3 main layers: the sclera, the uvea, and the retina.

 Sclera The sclera is the tough, white covering over most of the outside of the eyeball.

 Uvea The uvea is the middle layer of the eyeball. The most melanomas of the eye develop.

  • The uvea has 3 main parts:
  • The iris is the colored part of the eye (blue/brown).
  • The choroid is a thin, pigmented layer lining the eyeball that sustains the retina and the front of the eye with blood.
  • The ciliary body covers the muscles inside the eye that change the shape of the lens so that the eye can focus on near or far distant objects. Cells that sort aqueous humor, the clear fluid in the front of the eye between the cornea and the lens.

 Retina The retina is the inner layer of cells in the back of the eye. It is made up of particular nerve cells that are sensitive to light. These light-sensing cells are allied to the brain by the optic nerve. When light enters the eye it passes through the lens, which focuses it on the retina. The pattern of light/image appearing on the retina is directly gone through the optic nerve to an area of the brain called the visual cortex.

Digital Dentistry- CAD/CAM Technology

Oral care has come a long way.  About 8000 years ago people used a “chewing stick” which was no more than a stick or twig with a pointed or frayed tip. Today we use computer aided design and manufacturing (CAD/CAM). That is quite a jump!  Today, there is an entire industry focused around improving your dental experience using technology.

The CAD/CAM as an acronym stands for computer-aided design or computer-aided manufacturing. This is used for producing precision tools and with its incorporation into the field of dentistry over the past 2 decades, the technology and metal-free materials has been utilized by dentists to provide dental candidates milled ceramic crowns, onlays &inlays, veneers and bridges.

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Computer Aided Design (CAD) and Computer Aided Manufacture (CAM) in restorative dentistry can be used to:

  • Reduce production time for copings and frameworks; increasing overall productivity
  • Introduce consistent and measurable accuracy
  • Provide evidence of product quality

The dentists are able to see a three dimensional model of your mouth on a computer screen, by using this sophisticated software.  They can also create dental restorations right in our office that would previously have been made by a laboratory.  The patient benefits are immense in terms of time and accuracy.

CAD/CAM technology is usually combined with other technologies to shorten time in the dentist chair and reduce the number of visits.  Prior to this technology, all major tooth restorations required dentists to make a mold of the tooth and send it to a lab. The lab would then carve and cast a crown, send it back to the dentist, and you would need to return for another appointment. In-office CAD/CAM technology reduces these steps and allows the dentist to make a crown while you wait.

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Restorations made with CAD/CAM technology will also fit the patient’s tooth better.  A better fit result in a stronger seal and a longer lasting result. Some restorations still need to be sent to the laboratory for expanded material choices or custom aesthetic work not possible with a same-day procedure.  The good news is that modern dental laboratories now also use CAD/CAM technology.  Dentists send digital scans to the laboratory instead of the old style “impressions” many patients are familiar with.  This digital scan is then taken into the laboratory’s CAD/CAM system and restorations are made more quickly and more accurately than when made from an impression.

This technology has changed the world of dentistry but it is not alone. Subsequent posts will look at other new technologies for everything from dental implants to financing.  Our patients can take comfort in the fact that very smart people are working hard to help dentists make your dental experience better.

Diabetes Management by Pharmaceutical Approach

Pharma Med Chem

Diabetes mellitus (DM) is one of the metabolic disorder which is generally referred to as Diabetes. In which there is increase in blood sugar level over a prolonged period. Diabetes is due to either the disability of the pancreas to produce enough insulin or the cells of the body not responding properly to the insulin produced. There are three main types of diabetes mellitus.

  • Type 1 DM – failure of the pancreas to produce enough insulin. This type of DM is previously referred to as “insulin-dependent diabetes mellitus” (IDDM) or “juvenile diabetes”.
  • Type 2 DM – It is a condition of the cells where they fail to respond to the insulin properly. This form was previously referred to as “non-insulin-dependent diabetes mellitus” (NIDDM) or “adult-onset diabetes”.
  • Gestational diabetes – It occurs when pregnant women without a previous history of diabetes develop high blood sugar levels.

Diabetes management aims to restore carbohydrate metabolism to a normal state. The treatment goals include effective control of blood glucose, blood pressure and lipids and to lower the risk of long-term consequences related with diabetes.

Diabetes Pharmacy aims at minimizing the chronic diabetic complications and to avoid acute problems of hyperglycemia or hypoglycemia. Adequate control of diabetes leads to lower risk of complications associated with unmonitored diabetes including kidney failure, blindness, heart disease and limb amputation. Prevention includes maintaining a healthy diet, regular physical exercise, a normal body weight, and avoiding use of tobacco and alcohol. Risk of Diabetes Mellitus can only be controlled by lowering the blood sugar levels.

Anti-diabetic medications which are available in the market where some can be consumed by mouth, such as metformin, while others are only available by injection such as GLP-1 agonists. Type 1 diabetes can only be treated with insulin, typically with a combination of regular and NPH insulin, or synthetic insulin analogs. Type II diabetes ca be controlled by Insulin sensitizers which address the core problem. Biguanides, Thiazolidinediones, Lyn Kinase Activators etc. are the Insulin Sensitizers used. Lifestyle, daily routine also affects blood sugar level. Maintaining the Healthy diet, Daily Exercise and proper intake of Medications can help in reducing the risk of Diabetes.